The State of Weight in Cystic Fibrosis: Understanding Nutritional Status and Individualizing Nutritional Care in the Modulator Era
Document Type
Article
Publication Title
Nutrition and Cystic Fibrosis in Children
Abstract
Abstract There is a well-established association between cystic fibrosis (CF) and malnutrition. Sev-eral comorbid conditions have also been associated with undernutrition in people with cystic fibrosis (PwCF). Highly effective modulator therapy has allowed for a paradigm shift altering disease progression and management. Modulator use has even been as-sociated with acceleration of weight trajectory causing overnutrition, which can lead to cardiovascular and metabolic comorbid conditions. This review explores how nutritional status is evolving in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators in people with CF, specifically in children. By synthesizing current research, we aim to support pediatric healthcare providers and nutritionists in delivering tailored, proactive nutritional care in this new therapeutic landscape.
Publication Date
7-31-2025
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Khemka, S., Hunter, S., Jones, J., Valentín-Martínez, K., Chadwick, C. B., & Bass, R. (2025). The State of Weight in Cystic Fibrosis: Understanding Nutritional Status and Individualizing Nutritional Care in the Modulator Era. Nutrients, 17(15), 2533. https://doi.org/10.3390/nu17152533
